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Gut flora may interfere with blood pressure medication

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Researchers at the University of Toledo in Ohio studied the effectiveness of a drug long used to combat hypertension in mice with normal gut microbiota, compared to mice with normal gut microbiota. microbiota had been wiped out by massive doses of antibiotics.

They found that animals in the second group responded significantly better to quinapril. They then determined that the bacterium coprococcus was in question, since it is able to degrade quinapril and another product, ramipril.

About 20% of patients diagnosed with hypertension suffer from a resistant form of the disease, in which even aggressive treatment fails to lower their pressure to acceptable levels. Faced with such a situation, the only option available to doctors is to add or remove drugs, or even change the dose, in the hope of finally pinpointing a winning strategy.

The study is very interesting, because the resistance to hypotensive drugs that are currently available is a very important issue.reacted Professor Benoît Arsenault, of the Faculty of Medicine at Laval University.

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If this study was conducted on mice, the researchers discovered an anecdotal human case that suggests that they are on the right track.

In 2015, theInternational Journal of Cardiology related the case of a woman suffering from long-standing resistant hypertension. But when the woman needed antibiotics for an infection, doctors managed to control her high blood pressure without medication for two weeks and then for six months with just one medication. His hypertension then began to resist treatment again.

American researchers agree that it is unrealistic to consider using antibiotics long-term to control hypertension. They believe, however, that a patient could alter their microbiota with probiotics, prebiotics or changes to their diet.

We know that humans have the same bacteria in their intestines as [souris]but that’s basically all we know at the moment.said Professor Arsenault, who warns that we will have to be patient before this discovery finds concrete applications in humans.

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So before you think we’ve discovered a major cause of hypotensive resistance in humans […] I think you have to take some and leave some.

For obvious reasons, he recalls, researchers are always much more eager to publish promising and spectacular results than studies that have failed. This creates a kind of publication bias which partly explains why preclinical results that sometimes make you dream are not always there when clinical studies begin..

Hypertension is the most common cardiovascular disease on the planet. She is nicknamed the silent killer since millions of people suffer from it without knowing it and it inflates the risk of other health problems, such as heart attacks and strokes.

The findings of this study were published by the medical journal Hypertension.

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