Home LATEST NEWS Gut microbiota linked to inflammatory diseases like arthritis

Gut microbiota linked to inflammatory diseases like arthritis

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It took a long time before it was realized that it had antibacterial activityadds Professor Boilard.

This protein interacts little with the membrane of human cells, but it has a great affinity for the membrane of bacteria. It binds to their membrane and splits it, releasing small molecules such as fatty acids. »

A quote from Éric Boilard, professor at the Faculty of Medicine at Laval University

In their work, the researchers studied the effect of the protein phospholipase A2-IIA on the intestinal microbiota of a line of transgenic mice. These rodents possess the human gene that codes for the protein, and as they age they develop manifestations of chronic inflammation.

These experiments revealed that phospholipase modifies the profile of lipids of bacterial origin which are found in the intestine.

By releasing fatty acids from bacterial membranes, the protein produces pro-inflammatory lipids that exacerbate chronic inflammation and increase the severity of arthritis symptoms in these mice. »

A quote from Eric Boilard

The first author of this work published in the Journal of Clinical Investigation-InsightHave (New window)Have (in English) is Étienne Doré, doctoral student-researcher at the Faculty of Medicine of Laval University.

Psoriasis and skin cancer

The action of phospholipase on the intestinal microbiota of mice also has repercussions on psoriasis, another inflammatory disease, as well as on skin cancer.

This discovery was made by Pr Makoto Murakami and his colleagues from the University of Tokyo and is the subject of an article which is published in the same journal.Have (New window)Have.

Three years ago, we realized that our respective teams were on the same track. We have agreed to collaborate in order to shed light on this new lead. »

A quote from Eric Boilard

These two discoveries could eventually help to develop new therapeutic treatments.

Local inhibition of phospholipase could attenuate the inflammatory process that exacerbates certain diseases. They [les travaux] also suggest that by blocking the pro-inflammatory lipids of bacterial origin produced in the intestine by this protein, we could reduce the symptoms of people suffering from systemic inflammatory diseases. The next step in our work is to test these ideas in patients with arthritis.concludes Professor Boilard.

Last July, American scientists showed that the role played by genetics in the bacterial composition of the intestinal microbiota is more important than previously thought.

Until now, most studies have shown that the gut microbiota is primarily shaped by a person’s lifestyle, including the foods and medications they consume.

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