The United States had 2,725 canceled flights since the start of the day, more than half of the 4,618 that were canceled globally, around 11 p.m. according to the FlightAware website.
In addition, 6,072 domestic flights to or from the United States were or were delayed on Saturday, out of a total of 11,136 for the day globally.
The most affected US airline is SkyWest, which had to cancel 23% of its flight plan, according to the site, followed by SouthWest (13%).
In the United States, Chicago airports were particularly affected, with about half of departing or arriving flights canceled, due to harsh weather conditions, with a snowstorm expected in that region overnight.
And passengers should experience another complicated day on Sunday, the day back from the Christmas holidays: the site reports 1,497 flights canceled for the United States alone, and 2,538 worldwide.
Global air travel remains severely disrupted by the highly contagious Omicron variant of COVID-19.
Many pilots and flight crew members are absent after contracting the virus, or are in contact and therefore in quarantine, forcing companies, which do not have enough staff to ensure the flights, to cancel them.
Around 7,500 flights were canceled by airlines across the world over Christmas weekend.