This discovery could lead to new treatment options, according to Dr. Olivier Fisette, co-signer of the study and computer analyst, who simulated the spike protein of the virus in order to observe its structure.
He explains that these simulations were able to show that it is possible to destabilize the structure of the spike protein of SARS-CoV-2.
Focus on protein disulfide bonds
All proteins have very specific three-dimensional structures and this is what allows them to perform their function., explains Dr. Fisette.
The search allowed us to focus on an item named
Disulfide bridges are necessary elements for the protein to maintain its structure in space. If these bridges are broken, some proteins can lose their structure, says Dr Fisette.
Research by this team has shown this to be the case with the spike protein that causes COVID-19.
Fisette, this protein becomes destabilized. “,” Text “:” If we break the four disulfide bridges that are present in a particular region of the spicule, says Dr.Fisette, this protein becomes destabilized. “}}”>If one breaks the four disulfide bridges that are present in a particular region of the spicule, says Dr. Fisette, this protein becomes destabilized.
The protein makes it possible to recognize receptors which are on the surface of the human cell in order to
anchor, he adds.
The research questionHave (New window)Have So is this: if the bridges are broken, does the virus lose its ability to cause COVID-19?
Dr Olivier Fisette is an IT analyst. How did his field of expertise fit into this research?
My contribution was to use a model of the spike protein, and to simulate this protein. , he explains.
Dr. Fisette makes the comparison with an airplane simulator, which makes it possible to imagine a device in flight to calculate the influence of the winds on its trajectory.
We take a protein, we simulate it in a computer and we wonder what’s going on.
Dr Fisette explains that simulations also allow you to do things that are impossible in reality, such as
break disulfide bridges and compare.
The main role of this research, explains Dr. Andrey Grishin, another co-signer of the study, is to be offered to any scientist who will use it as a starting point for their research.
It is above all a matter of gaining knowledge to advance research, he notes.